Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.

نویسندگان

  • M Heep
  • U Rieger
  • D Beck
  • N Lehn
چکیده

A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 44 4  شماره 

صفحات  -

تاریخ انتشار 2000